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Dr. George R. Hoffmann
Professor
Ph. D., University of Tennessee
Genetics, Toxicology, and Botany
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My primary research interests are in mutation research and genetic toxicology. My students and I study the induction of point mutations, genetic recombination, and chromosomal damage using methods based in microbial genetics and human cytogenetics. The focus is on mechanisms by which mutagenic and carcinogenic chemicals and radiation cause genetic damage. Related interests include relationships between chemical structure and biological activity, the analysis of dose-response relationships, and applications of microbial and cytogenetic assays as models for predicting and interpreting genotoxic effects. Recent research projects concern the induction of mitotic recombination in yeast, mechanisms of mutagenesis in bacteria, the induction of chromosomal damage in human lymphocytes by the cancer chemotherapy drug bleomycin, and interactions among mutagenic treatments.
Hoffmann, G.R., M.V. Ronan, K.E. Sylvia and J.P. Tartaglione. 2009. Enhancement of the recombinagenic and mutagenic activities of bleomycin in yeast by intercalation of acridine compounds into DNA. Mutagenesis 24:317-329. get PDF Hoffmann, G.R. 2009. A perspective on the scientific, philosophical, and policy dimensions of hormesis. Dose-Response: 7:1–51. get PDF Preston, R.J., and G.R. Hoffmann. 2008. Genetic Toxicology. In “Casarett and Doull's Toxicology: The Basic Science of Poisons,” C.D. Klaassen, ed., McGraw-Hill, New York, 7th Edition, Chapter 9, pp. 381-413. Hoffmann, G.R. and W.E. Stempsey. 2008. The Hormesis concept and risk assessment: Are there unique ethical and policy considerations? Hum. Exper. Toxicol. 27:613-620 (http://www.belleonline.com/newsletters/volume14/vol14-3.pdf). Preston, R.J. and G.R. Hoffmann. 2008. Genetic Toxicology. In “Casarett and Doull's Toxicology: The Basic Science of Poisons,” C.D. Klaassen, ed., McGraw-Hill, New York, Seventh Edition, pp. 381-413. Hoffmann, G.R., Gessner, G.S., Hughes, J. F., Ronan, M.V., Sylvia, K.E., & Willett, C.J. 2007. Modulation of the genotoxicity of bleomycin by amines through noncovalent DNA interactions and alteration of physiological conditions in yeast. Mut. Res. 623: 41–52. get PDF Freeman, K.M. & Hoffmann, G.R. 2007. Frequencies of mutagen-induced coincident mitotic recombination at unlinked loci in Saccharomyces cerevisiae. Mut. Res. 616: 119-132. get PDF Hoffmann, G.R., Yin, C.C., Terry, C.E., Ferguson, L.R. & Denny, W.A. 2006. Frameshift Mutations Induced by Four Isomeric Nitroacridines and Their des-Nitro Counterpart in the lacZ Reversion Assay in Escherichia coli. Environmental and Molecular Mutagenesis 47:82-94 .get PDF Calabrese, E.J., J.W. Staudenmayer, E.J. Stanek III, and G.R. Hoffmann. 2006. Hormesis outperforms threshold model in NCI anti-tumor drug screening database. Toxicol. Sci., 94: 368-378. get PDF Hoffmann, G.R., M.A. Calciano, B.M. Lawless, and K.M. Mahoney. 2003. Frameshift mutations induced by three classes of acridines in the lacZ reversion assay in Escherichia coli: Potency of responses and relationship to slipped mispairing models. Environ. Mol. Mutagen., 42:111-121 .get PDF Hoffmann, G.R., D. J. Crowley, and P. J. Theophiles. 2002. Comparative potencies of induction of point mutations and genetic duplications by the methylating agents methylazoxymethanol and dimethyl sulfate in bacteria. Mutagenesis, 17:439-444. get PDF Hoffmann, G.R., A.M. Sayer, and L.G. Littlefield. 2002. Higher frequency of chromosome aberrations in late-arising first-division metaphases than in early-arising metaphases after exposure of human lymphocytes to X-rays in G0. Int. J. Radiat. Biol., 78:765-772. get PDF Hoffmann, G.R., J. Buccola, M.S. Merz, and L.G. Littlefield. 2001. Structure-activity analysis of the potentiation by aminothiols of the chromosome-damaging effect of bleomycin in G0 human lymphocytes. Environ. Mol. Mutagen., 37:117-127. get PDF Hoffmann, G. R., J-B Regine, R. P.P. Fuchs. 2001. Induction of-2 frameshift mutations by 2-nitrofluorene, N-hydroxyacetylaminofluorene, and N-2-acetylaminofluorene in reversion assays in Escherichia coli strains differing in permeability and acetyltransferase activity. Mut. Res 493: 127-137. get PDF Hoffmann, G.R., A.M. Sayer, E.E. Joiner, A.F. McFee, and L.G. Littlefield. 1999. Analysis by FISH of the spectrum of chromosome aberrations induced by x rays in human lymphocytes and their fate through mitotic divisions in culture. Environ. Molec. Mutagen., 33:94-110. get PDF Hoffmann, G.R., R.A. Shorter, J.L. Quaranta, and P.D. McMaster. 1999. Two mechanisms of antimutagenicity of the aminothiols cysteamine and WR-1065 in Saccharomyces cerevisiae. Toxicol. In Vitro., 13:1-9. get PDF Hoffmann, G.R., and R.P.P. Fuchs. 1997. Mechanisms of frameshift mutations: Insight from aromatic amines. Chem. Res. Toxicol., 10:347-359. get PDF Hoffmann, G.R., S.M. Deschênes, T. Manyin, and R.P.P. Fuchs. 1996. Mutagenicity of acridines in a reversion assay based on tetracycline resistance in plasmid pBR322 in Escherichia coli. Mutation Res., 351:33-43. get PDF Hoffmann, G.R., J.L. Quaranta, R.A. Shorter, and L.G. Littlefield. 1995. Modulation of bleomycin-induced mitotic recombination in yeast by the aminothiols cysteamine and WR-1065. Molec. Gen. Genet., 249:366-374. get PDF Hoffmann, G.R., and L.G. Littlefield. 1995. Enhancement of the activity of bleomycin by cysteamine in a micronucleus assay in G0 human lymphocytes. Toxicol. Lett., 78:147-151. get PDF Hoffmann, G.R., A.M. Sayer, and L.G. Littlefield. 1994. Potentiation of bleomycin by the aminothiol WR-1065 in assays for chromosomal damage in G0 human lymphocytes. Mutation Res., 307:273-283. get PDF Hoffmann, G.R. 1992. Bacterial assays for recombinagens. Mutation Res., 284:125-146. get PDF
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