Animal Physiology (Biology 390) Class Materials and Schedule Fall 2008 College of the Holy Cross Dr. Ken Prestwich	Animal Physiology Art. Diving response experiment. © 2003 by Andrew Pina, CHC Biology '04.

Preface -- Introduction to Animal Physiology
Cl #1 9 / 3 (W)	Introduction to physiology and its central concept -- regulation Class #1 PP
Part 1. Metabolism and Temperature
Cl #2 9 / 5 (F)	Finish regulation overview. An overview of energy transformations -- General principles of bioenergetics
Cl #3 9 / 8 (M)	An overview of the biochemistry of metabolism. The regulation of ATP concentration. Catabolic pathways: Aerobic metabolism. Lab #1: Regulation of plasma glucose
Cl #4 9 / 10 (W)	The RQ concept and its uses (aerobic metabolism notes) Anaerobic metabolism Class # 1.5 to 4 PP -- REVISED SLIGHTLY 9/5 RQ Problems RQ Prob. Solns.
Cl #5 9 / 12 (F)	The regulation of metabolism Activity metabolism. Scope and Efficiency Problems Study Questions on Metabolism Scope and Efficiency Prob. Solns.
Cl #6 9 / 15 (M)	Finish activity metabolism Class # s 5&6 PP Lab #2: Interpretation of experimental results and models in physiology.
Cl #7  9 / 17 (W)	Metabolism and body size -- an introduction to scaling Class # 7 PP Scaling Problems Solutions to Scaling Problems Questions on Scaling
Cl #8 9 / 19 (F)	Ectothermy: temperature regulation and metabolism Textbook Reading Assignment: Ch. 6--Temperature and Ch. 7--Temperature Regulation (entire unit)
Cl #9 9 / 22 (M)	Temperature and metabolism, continued. Lab #3: Metabolic Rates: Body Size and Temperature
Cl #10 9 / 24 (W)	Heliothermy and endothermy, continued Euthermy Problems Evaporative Water Loss Problems Ectothermy and Q10 problem Euthermy problems solutions Evaporative Water Loss Problem Solutions Ectothermy and Q10 problem Solutions Temperature Regulation Study Questions
Cl #11 9 / 26 (F)	Closing comments on endothermy and its evolution. -- END MATERIAL FOR EXAM #1

Part 2. The Physiology of Contractile Systems A. The Biochemistry of Contraction
Cl #12 9 / 29 (M)	Muscle morphology and the biochemistry of contraction Exam #1 from 2 to 4 PM in the lab period.
Cl #13 10 / 1 (W)	Excitation - Contraction Coupling Begin Skeletal muscle biophysics
Part 2: The Physiology of Contractile Systems B. Elasticity and Contraction.
Cl #14 10 / 3 (F)	Finish skeletal muscle biophysics
Cl #15 10 / 6 (M)	Integrated skeletal muscle function Lab #4: Skeletal Muscle Function
Cl #16 10 / 8 (W)	EC Coupling in Smooth muscles
Part 3: Excitable Cells
Cl #17 10 / 10 (F)	Begin a consideration of Electricity for physiology students --- review, hopefully. Information, signals, and biological systems -- a broad, almost philosophical overview of signalling and information.
10 / 13 (M)	No Class or Lab -- Columbus Day Break (Oct. 13 and 14)
Cl #18 10 / 15 (W)	Resting potentials, continued. Excitable cell problems Excitable cell problems solutions Voltage clamp problems Voltage clamp solutions to problems
Cl #19 10 / 17 (F)	Action potentials and the voltage clamp
Cl #20 10 / 20 (M)	Finish APs Transmission of bioelectrical potentials Lab #5: Neuronal function simulations and compound action potentials
Cl #21 10 / 22 (W)	Finish intracellular transmission. Synaptic transmission PP for bioelectrical potential transmission (because I promised).
Cl #22 IN PART 10 / 24 (F)	An overview of the somatic and autonomic nervous systems (maybe) -- its memorization in any case. END MATERIAL FOR EXAM #2
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Part 4: Circulation
Cl #22 IN PART  10 / 24 (F)	Introduction to the Circulation (Introduction to circulations HO) Textbook Reading Assignment for entire unit: Ch. 3 -- Circulations
Cl #23 10 / 27 (M)	Basic Fluid Dynamics Vasculature Lymph Exam #2 from 2 to 4 PM in the lab period.
Cl #24 10 / 29 (W)	Finish the vasculature and lymphatic systems. Same assignment as last two classes.
Cl #25 10 / 31 (F)	Begin cardiac physiology -- Overview, conduction, pacemaking, chronotropic and ionotropic effects. Cardiac physiology HO
Cl #26 11 /3 (M)	Finish" the heart". Lab #6: Performance measures for the circulation and respiratory volumes. The EKG and its interpretation .
Cl #27 11 / 5 (W)	Summary diagram for the heart How arteries alter cardiac output and influence cardiac work. Circulation Problems Atherosclerosis Peripheral Resistance Solutions Solutions
Cl #28 11 / 7 (F)	The regulation of the "typical" mammalian circulation
Part 5: The Regulation of Fluid and Ionic Balance
Cl #29 11 / 10 (M)	Kidney anatomy, function, and the clearance concept HO Lab #7: Begin Integrated respiration and circulation.
Cl #30 11 / 12 (W)	Filtration and clearance -- same notes as previous class. Excretion Problems Renal Clearance Lung and Renal Clearance Glucose Clearance Solutions (one correction made on 11/7 -- thanks Mike! Solutions Solutions   Fluid compartments handout -- for those who want to read about this topic
Cl #31 11 / 14 (F)	Finish excretion (no joke!) -- water balance-- Discussion of textbook reading assignment: Ch. 9 -- Excretion END MATERIAL FOR EXAM #3
Part 6: Respiratory Physiology A. Overview and the comparative physiology of respiration
Cl #32 11 / 17 (M)	Overview of respiratory systems A survey of animal respiratory systems -- means of dealing with the constraint of diffusion Gas Laws Solubility Problems Siren Metabolism and Diffusion Problem Solutions Solutions Solutions   Lab #8: Integrated physiology week 2
Part 6: Respiratory Physiology B. Blood gas transport
Cl #33 11 / 19 (W)	The behavior of respiratory gases in watery solutions S-N Text Reading Assignment Ch. 2 -- Blood  Oxygen transport problems Fick's Principle and hemoglobin problem   Solutions   Solution

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Lab Schedule General Lab Information
SEPT. 8	Lab 1: Plasma glucose regulation. Instrumentation for Glucose Lab GTT Simulation Problems Solutions to Problems   bG lab assignment (due Friday Sept 21 by start of class) The cumulative results of the blood glucose lab (includes our lab)
SEPT. 15	Lab 2: PART 1. Glucose lab data analysis and glucose regulation simulation -- IN BIO DEPT COMPUTER LAB PART 2: Glucose tolerance test simulation Statistics in Experimental Analysis   Using Excel for Data Analysis and Graphing Data Gathering and Signal Conditioning  Making Multiple Plots on One Graph Using Excel Adding Error Bars Using Excel
SEPT.22	Lab 3: Spirometry and the measurement of respiratory volumes. Resting metabolism. Measurement of Resting Metabolic Rate in Humans Measuring Respiratory Volumes Background Protocol
SEPT. 29	EXAM #1 -- 2 TO 4 PM 4 TO 5 PM -- LAB -- AN INTRODUCTION TO USING BIOPAC SOFTWARE (SEE BELOW)
OCT. 6	Lab 4: Muscle function -- emg and force. Assignment of lab presentations.
OCT. 13	NO LAB -- Columbus Day Break
OCT. 20	Lab 5: Neuronal simulations and compound extracellular potential -- the electroencephalogram (EEG). Neuron simulation handout Biopac handouts for EEG labs. Campus access only EEG, part 1 EEG, part 2
OCT. 27	EXAM #2 -- 2 to 4 PM
NOV. 3	Lab 6: The measurement circulatory and respiratory parameters: blood pressure (limb and chest leads.), the electrocardiogram, and lung volumes. Discussion of the EKG coupled with a presentation on how to read EMGs.   Measurement of blood pressure and heart rate
NOV. 10	Lab 7: Begin integrated respiration and circulation   Respiration and circulation, week 1 Measurement of Respiratory Volumes (in lab) Measurement of forced Expiratory Volumes
NOV. 17	:Lab 8:Respiration and circulation, week 2. Regulation of breathing. Respiration and circulation, week 2 Minute Volumes and Breathing Rates (be sure to do this problem before lab) Regulation of Breathing (in lab)
NOV. 24	EXAM #3 -- 2 TO 4 PM
DEC. 1	Lab 9: Time for short individual projects -- or respiratory volume exercises.
DEC. 8	Lab 10: Presentations for respiration and circulation labs.

 

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