Animal Physiology (Biology 390) Class Materials and Schedule Fall 2008 College of the Holy Cross Dr. Ken Prestwich	The Fall 2008 Dream Animal Physiology Class. L to R: (back) Luke Botting '09, GatorBoy, Chadd Baer '09, Greg Leslie '09, Taylor Glor '10, Theron Fussell '10, Laura Cerroni '09, Amy Trojanowski '09, Dan York '10, Mike Kryzak '09 & Andrew Moczula. Front: Matt Partain '09.5, Natasha Tobarran '09, Megan Cooper '09, Jen Olson '09, and Chris Gibson '09.

Cl #1 9 / 3 (W)	Preface -- Introduction to Animal Physiology Introduction to physiology and its central concept -- regulation Class #1 PP -- CHC access only
Cl #2 9 / 5 (F)	Part 1. Metabolism and Temperature An overview of energy transformations -- General principles of bioenergetics Class #2 PP -- CHC access only
Cl #3 9 / 8 (M)	class & lab were cancelled
Cl #4 9 / 10 (W)	Finish overview of energy x0forms. An overview of the biochemistry of metabolism PP for cl#4 -- CHC access only
Cl #5 9 / 12 (F)	The regulation of ATP concentration. Catabolic pathways: Aerobic metabolism.
Cl #6 9 / 15 (M)	The RQ concept and its uses (aerobic metabolism notes) Anaerobic metabolism RQ Problems RQ Prob. Solns. Lab Week #1: Measuring metabolism: Metabolic rate and body size.
Cl #7  9 / 17 (W)	The regulation of metabolism PP for cl#5&6 -- CHC access only Scope and Efficiency Problems Study Questions on Metabolism Scope and Efficiency Prob. Solns.
Cl #8 9 / 19 (F)	NO CLASS
Cl #9 9 / 22 (M)	Activity metabolism. begin Ectothermy: temperature regulation and metabolism Textbook Reading Assignment: Ch. 6--Temperature and Ch. 7--Temperature Regulation (entire unit) PP for cl#7 & 9 -- CHC access only   Lab #2: Metabolism and temperature
Cl #10 9 / 24 (W)	Finish activity metabolism Temperature and metabolism
Cl #11 9 / 26 (F)	Temperature and metabolism in ectotherms. Q10. (same as previous notes) Ectothermy and Q10 problem Ectothermy and Q10 problem Solutions Temperature Regulation Study Questions PP for cl#10 up to exam -- CHC access only -- END MATERIAL FOR EXAM #1 Heliothermy and endothermy.
Cl #12 9 / 29 (M)	Finish ectothermy with heat transfer and heliothermy. Exam #1 from 2 to 4 PM in our classroom.
Cl #13 10 / 1 (W)	Euthermic endothermy (same as previous notes) Euthermy Problems Evaporative Water Loss Problems Euthermy problems solutions Evaporative Water Loss Problem Solutions Temperature Regulation Study Questions (Same as above)
Cl #14 10 / 3 (F)	Finish euthermy Endothermy and heliothermy PP -- CHC access only
Cl #15 10 / 6 (M)	Part 2. The Physiology of Contractile Systems A. Introduction and the Biochemistry of Contraction Muscle morphology and the biochemistry of contraction Lab #4: Skeletal Muscle Function
Cl #16 10 / 8 (W)	Excitation - Contraction Coupling in skeletal muscle (SkM) Skeletal Muscle PP -- CHC access only
Cl #17 10 / 10 (F)	EC Coupling in Smooth muscles Smooth Muscle PP -- CHC access only
10 / 13 (M)	No Class or Lab -- Columbus Day Break (Oct. 13 and 14)
Cl #18 10 / 15 (W)	Part 2: The Physiology of Contractile Systems B. Elasticity and Contraction. Skeletal muscle biophysics Skeletal Muscle Biophysics PP -- CHC access only
Cl #19 10 / 17 (F)	Integrated skeletal muscle function Integrated skeletal muscle function PP -- CHC access only
Cl #20 10 / 20 (M)	Finish integrated skeletal muscle function. -- PP is with previous class. Some discussion of textbook questions dealing with muscle. Schmidt-Nielson Ch. 10 Movement Chapter Study Questions Part 3: Excitable Cells Resource -- Electricity for physiology students - (a review, hopefully)   Lab #5: Neuronal function simulations and compound action potentials
Cl #21 10 / 22 (W)	Information, signals, and biological systems -- a broad, almost philosophical overview of signalling and information.  The resting potential Electricity review and Information, signals overview PP
Cl #22 IN PART 10 / 24 (F)	Finish resting potentials -- Exam #2 ends with resting potentials Excitable cell RMP problems Excitable cell problems solutions Resting potential PP An introduction to "moving potentials" and membrane models -- notes have moved to class #23
Cl #23 10 / 27 (M)	Action potentials and the voltage clamp Voltage clamp problems Voltage clamp solutions to problems Exam #2 from 2 to 4 PM in the lab period.
Cl #24 10 / 29 (W)	Action potentials, continued Action potential PP
Cl #25 10 / 31 (F)	Transmission of bioelectrical potentials and Synaptic transmission
Cl #26 11 /3 (M)	finish transmission of bioelectric potentials. Begin synaptic transmission (truncated version -- see PPT)   Moving potentials PP
Cl #27 11 / 5 (W)	Finish synaptic transmission Additional Excitable Cell Study Questions Synaptic x-mission PP
Cl #28 11 / 7 (F)	An overview of the somatic and autonomic nervous systems Autonomic-Somatic NS PP Part 4: Circulation Introduction to the Circulation (Introduction to circulations HO (will not be covered in class but you are expected to know this material) Basic Fluid Dynamics Textbook Reading Assignment for entire unit: Ch. 3 -- Circulations
Cl #29 11 / 10 (M)	Vasculature & Lymph   Vasculature PP Lab #7: EKG interpretation
Cl #30 11 / 12 (W)	Cardiac physiology HO Summary diagram for the heart Vertebrate Heart PP (end of exam 3 material) Circulation Problems Atherosclerosis Peripheral Resistance Fick Principle Problem Solutions Solutions Solutions
Cl #31 11 / 14 (F)	Cardiac work diagram, overall view of heart operation -- exam material ends here How arteries alter cardiac output and influence cardiac work Circulation and blood pressure PP
Cl #32 11 / 17 (M)	Overall control of mammalian circulations Overall circulatory regulation models PP Exam #3 from 2 to 4 PM in the lab period (no lab)
Cl #33 11 / 19 (W)	finish circulatory regulation, discuss a few applications (e.g., digoxin and congestive heart failure, cv shock). Part 5: The Regulation of Fluid and Ionic Balance Begin Kidney anatomy, function, and the clearance concept HO
Cl #34 11 / 21 (F)	Filtration and clearance -- same notes as previous class. Excretion PP -- CHC access only Excretion Problems Renal Clearance Lung and Renal Clearance Glucose Clearance Solutions Solutions Solutions Fluid compartments handout -- for those who want to read about this topic
Cl #35 11 / 24 (M)	Part 6: Respiratory Physiology A. Overview and the comparative physiology of respiration & behavior of gases in watery solutions. Overview of respiratory systems   Comparative Respiration --PP CHC access only Lab #8: Integrated physiology week 2
11 / 25 through 11 / 30 ---- THANKSGIVING VACATION
Cl #36 12 / 1 (M)	A survey of animal respiratory systems -- means of dealing with the constraint of diffusion Q&A only -- sorry, but we must get through this to have a complete view of the respiratory system. Gas Laws Solubility Problems Siren Metabolism and Diffusion Problem Solutions Solutions Solutions Lab #9: Respiration and Circulation, week 2 (Individual projects)
Cl #37 12 / 3 (W)	Part 6: Respiratory Physiology B. Blood gas transport The behavior of respiratory gases in watery solutions -- this is what we will spend most of our class time on! Oxygen Transport in Blood PP S-N Text Reading Assignment Ch. 2 -- Blood  Oxygen transport problems Fick's Principle and hemoglobin problem   Solutions Solution
Cl #38 12 / 5 (F)	Finish blood oxygen transport. Part 6: Respiratory Systems C. The mechanics of breathing in mammals The mechanics of breathing Compliance Reference Materials
Cl #39 12 / 8 (M)	Static analysis of mammalian lungs The dynamics of breathing Respiratory System Mechanincs PP Lab #10: Discussion of previous labs
EXTRA CREDIT MATERIAL	Blood, breathing and acid-base balance Acid-Base PP Acid/Base Problems RespProb7_pHreview RespProbs --Acid-base RespProb9_Acid-baseDisturb Solutions Solutions Solutions
EXTRA MATERIALS -- NOT ON THE FINAL EXAM Alveolar - Blood Gas Exchange Extreme conditions and gas exchange -- high altitude and diving respiratory physiology Lung/Blood Problems RespProb10_blGas&Vd.pdf RespProb11_RespCalcs.pdf Solutions Solutions   RespProb12_CO2-O2 Diagram.pdf Dilution Problem Diving and Dead Space IN LAB Solution Solution
12 / 10 (W)	Study Period Begins
Comprehensive Final Exam Wednesday December 17 from 8:30 to noon

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Lab Schedule General Lab Information
SEPT. 8	Lab cancelled
SEPT. 15	Lab 1: Spirometry and the measurement of respiratory volumes. Resting metabolism. Measurement of Resting Metabolic Rate in Humans Measuring Respiratory Volumes Background Protocol
SEPT.22	Lab 2: Temperature and metabolism Animal Physiology Art. Cold room.© 2003 by Andrew Pina, CHC Biology '04.
SEPT. 29	EXAM #1 -- 2 TO 4 PM -- Includes lecture material and 20 point lab exam. 4 TO 5 PM -- LAB -- AN INTRODUCTION TO USING BIOPAC SOFTWARE (SEE BELOW)
OCT. 6	Lab 4: O 5 PM -- LAB -- AN INTRODUCTION TO USING BIOPAC SOFTWARE (SEE BELOW) Muscle function -- emg and force.
OCT. 13	NO LAB -- Columbus Day Break
OCT. 20	Lab 5: Neuronal simulations and compound extracellular potential -- the electroencephalogram (EEG). Neuron simulation handout Biopac handouts for EEG labs. Campus access only EEG, part 1 EEG, part 2
OCT. 27	EXAM #2 -- 2 TO 4 PM
NOV. 3	Lab 6: The measurement circulatory and respiratory parameters: blood pressure (limb and chest leads.), the electrocardiogram, and lung volumes. Discussion of the EKG coupled with a presentation on how to read EMGs.   Measurement of blood pressure and heart rate
NOV. 10	EKG lab 2
NOV. 17	EXAM #2 -- 2 to 4 PM
NOV. 24	Animal Physiology Art. Diving response experiment. © 2003 by Andrew Pina, CHC Biology '04.   Lab 7: Begin integrated respiration and circulation Respiration and circulation, week 1 Measurement of Respiratory Volumes (in lab) Measurement of forced Expiratory Volumes
DEC. 1	:Lab 8:Respiration and circulation, week 2. Regulation of breathing. Respiration and circulation, week 2 Minute Volumes and Breathing Rates (be sure to do this problem before lab) Regulation of Breathing (in lab)
DEC. 8	Lab 10: Discussion of labs -- BIOLOGY DEPARTMENTAL COMPUTER LAB	Luke, Matt and Taylor -- our center, kicker and holder--after the Nov. 8 victory over Fordham. You can play football at a high level and do well in a tough course, if you work at it! Phys 2008.

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